Affinity chromatography is a chromatographic technique that uses the specific affinity between biomolecules for separation. Specifically, affinity chromatography involves immobilizing a ligand on an inert carrier, and the target protein in the mixture is specifically bound to the ligand and thus captured, while the extraneous impurity components are washed off with the mobile phase, and then a suitable eluent is selected to elute the target protein from the carrier, resulting in a single component of purified material. Learn more: Difference Between Protein A/G/L

Research has provided evidence that the presence of IgM and IgA donor-specific antibodies (DSA) in the recipient's serum is linked with a greater risk of graft failure. However, the understanding of how these non-IgG antibodies contribute to transplant rejection is still in its infancy. IgM antibodies, the largest in size amongst all antibodies, are usually the first responders to infections. Learn more: Non-IgG Antibodies in Transplant Rejection

After years of hard working in exploring application of exosomes, Creative Biolabs has got all the necessary experience and technologies of exosome engineering. The most usually used approaches are loading naïve exosomes isolated from parental cells ex vitro, loading parental cells with a drug, and transfecting/infecting parental cells with DNA encoding therapeutically active compounds. We will respectively give a brief introduction to each of them. Learn more: Drug Loading into exosome

A CDx assay, according to the US-America Food and Drug Administration (FDA) guidance, is defined as an IVD device that provides information that is essential for the safe and effective use of a corresponding therapeutic product. It is required when drug/biologic has a specific genetic or biological target not present in all patients with a particular disease. Therefore, the test can be used to identify patients most likely to respond to therapeutic drug or biologic, as well as patients at lower or higher risk for a particular side effect. Learn more: cdx biomarker

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. Learn more: hes1 antibody

There have 2 populations of T lymphocyte, αβ T cells, γδ T cells. They are distinguished by the expression of either an αβ T-cell receptor (TCR) or a γδ TCR. γδ T cells are a small population of lymphocytes, accounting for 0.5%–5% of overall T lymphocytes and have variable tissue distribution in the body. γδ T cells have been revealed to play a pivotal role in cancer progression through innate or adaptive immune responses. Learn more: gamma delta t cell line

In recent years, immune checkpoint molecules, like CTLA-4, have become a powerful tool for preventing immune damage. The immune response of T cells controlled by checkpoint molecules can avoid unwanted activation in disease treatments. Up to now, CTLA-4 molecules have shown an indispensable role in regulating self-tolerance of autoimmune diseases, the T-cell response of infectious diseases, as well as anti-tumor activity of various cancers. Learn more: immune checkpoint CTLA-4

Macrophages are able to initiate a particular type of inflammatory response via the release of a certain pattern of cytokines. They play a major role as immunoregulatory cells. Creative Biolabs has built a highly experienced team of scientists and quality staff that have a long history in macrophage isolation and culture. Human monocyte, human alveolar, murine peritoneal cavity, murine bone marrow, murine lung, and murine adipose tissues are available for macrophage isolation and culture. Learn more: Human Macrophage Isolation and Culture

Neurotoxicity screening is a relatively new field, and its progress is limited by factors that complicate neurotoxicology assessment. It has been proved that episodes of neurotoxic illness can be induced by chemicals, such as Lucel-7. According to the analysis of structure-activity relationships (SARs), only a small fraction of neurotoxicants can be identified. In this case, a series of in vivo and in vitro tests are necessary. Learn more: neurotoxicity study

Point-of-care technology (POCT) diagnostic systems are tools that can rapidly lead to in vitro diagnostic (IVD) results by non-trained personnel at a patient site in varieties of locations such as the field, the home, the ambulance, or the hospital. To this day, diagnostic tests are typically operated at laboratories equipped with bench-top analyzers and managed by trained personnel. Learn more: microfluidic real-time

Base on our perfect AOC platform, AOCs can be designed, engineered, and developed to combine the tissue and disease selectivity of monoclonal antibodies (mAbs) and the precision of oligonucleotide-based therapies to access previously undruggable tissue and cell types, and more effectively target underlying genetic drivers of diseases. Creative Biolabs provides comprehensive AOC development services for our honor clients and the AOCs candidates derived from our platform will have the potential to offer distinct advantages over ON itself.

A sandwich ELISA measures antigen between two layers of antibodies (capture and detection antibody). The target antigen must contain at least two antigenic sites capable of binding to antibodies. We provide sandwich elisa detection service with high sensitivity and high specificity for global customers.

IgM is the largest antibody among the five major classes of immunoglobulin. It is generated as a B cell membrane-bound monomer and a secreted pentamer. IgM is also called "natural antibody" due to its ability to bind to specific antigens without prior immunization. Learn more: Non-IgG Antibodies for Prostate Carcinoma Treatment

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. Learn more: gabra1 antibody

The central nervous system (CNS) is prone to a variety of diseases, especially prevalent in the aging process. Common CNS diseases include epilepsy, AD, PD, affective disorders, and cognitive impairment. The exploration of function mechanisms and pathological pathways of CNS is a complex and challenging process. Fortunately, multiple animal models that mimic neurological disorders in humans have been successfully established. Learn more: In Vivo ALS

Previous research has shown that the hypothalamus and substantia nigra are the main sources of dopamine production in the brain. In adult mammals, dopamine synthesized in the hypothalamus, mostly in neurons that localized in the insert zones, the periventricular and arcuate nuclei, is involved in neuroendocrine regulation as a) a neurotransmitter controlling the secretory activity of peptidergic target neurons, b) a neuromodulator regulating the release of neurohormones from neighboring peptidergic axons into the median eminence, and c) a neurohormone passing via the hypophyseal portal circulatory system to the anterior lobe of the hypophysis, where it inhibits prolactin secretion. Learn more: ips dopaminergic neurons

C-reactive protein (CRP) is an acute-phase serum protein. It is a member of the pentraxin family, produced mostly by cells in the liver in response to a variety of inflammatory cytokines. The levels of CRP in the blood are closely associated with the degree of inflammatory responses. Learn more: CRP Assay Kit

Recombinant monoclonal antibody to Human CD20. Tositumomab is a drug for the treatment of follicular lymphoma. It is an IgG2a anti-CD20 monoclonal antibody derived from immortalized mouse cells. Tositumomab is applied in a sequential infusion followed by iodine (131I) tositumomab, which is the same antibody covalently bound to the radionuclide iodine-131 (131I). 131I emits both beta and gamma radiation and decays with a half-life of 8 days.

Many hybridoma researchers have lost an important hybridoma cell line because of instability, mechanical breakdown of a freezer, or contamination. Hybridoma rescue has become a great challenge worldwide. Creative Biolabs possesses diverse flexible, interactive, and cost-effective hybridoma development systems. We now have the capability and technology platforms to offer you diverse Hybridoma Rescue services.

mRNA synthesized by the IVT method has greatly facilitated vaccine development. As one of the leading biotechnology companies, Creative Biolabs is dedicated to providing professional IVT synthesis of mRNA service.