In recent years, immune checkpoint molecules, like CTLA-4, have become a powerful tool for preventing immune damage. The immune response of T cells controlled by checkpoint molecules can avoid unwanted activation in disease treatments. Up to now, CTLA-4 molecules have shown an indispensable role in regulating self-tolerance of autoimmune diseases, the T-cell response of infectious diseases, as well as anti-tumor activity of various cancers. Learn more: immune checkpoint CTLA-4